Nerivio is indicated for acute and/or preventive treatment of migraine with or without aura in patients 8 years of age or older. It is a prescription-use, self-administered device for use in the home environment at the onset of migraine headache or aura for acute treatment, or every other day for preventive treatment.

Nerivio has not been evaluated in people with congestive heart failure (CHF), severe cardiac or cerebrovascular disease, or those under the age of 8. Nerivio should only be applied on the upper arm over dry, healthy skin, with normal physical sensation and away from proximity to cancerous lesions. Do not use the device on an arm with a metallic implant. In such cases, consider using it on the other upper arm. Use the device according to user and healthcare provider instructions. If treating more than once a day, wait 30 minutes and switch arms between treatments. Administering treatment more than 6 times per day is unlikely to provide any additional benefit.

Nerivio should not be used by people with uncontrolled epilepsy, an active implantable medical device, such as a pacemaker, hearing aid implant, or any implanted electronic device. Such use could cause electric shock, electrical interference, or serious injuries or medical conditions.