Dr. Blumenfeld, neurologist, explains the science behind Nerivio

How Does Nerivio Work?

Nerivio® is the first and only FDA-cleared device to utilize Remote Electrical Neuromodulation (REN) to prevent and treat migraine. Clinical trials demonstrate that Nerivio provides consistent relief of pain and associated migraine symptoms. It is safe and well-tolerated with no systemic side effects or concern for medication overuse.

See clinical data
A discreet,
disrupting to
daily routine
Can be used
instead of or
with medications

Novel Mechanism of Action

Nerivio stimulates Aδ and C fibers in the upper arm. Stimulation of these pain fibers sends messages to the pain regulation centers in the brainstem. This activates the body’s Conditioned Pain Modulation (CPM) system, activating the descending pain inhibitory pathways. Descending inhibitory signals travel to the trigeminal cervical complex where serotonin and norepinephrine are released. Nerivio’s activation of the body’s endogenous analgesic system has a global impact on pain.

Nerivio MOA
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