Additional Research

Preventive treatment (episodic & chronic)

Health economics analysis (coming soon)

Acute treatment of episodic migraine

Adolescents with migraine

Comparison of Nerivio and medications

Episodic migraine

Chronic migraine


Real-world studies

Real world evidence in adults

In-app behavioral intervention

In-app behavioral intervention

Menstrual migraine

Menstrual migraine

Independent scientific support

Nerivio’s scientific reviews

Nerivio’s scientific reviews



Menstrual Migraine

Nierenburg et al., Pain and Therapy, 2021 Read More

Estimations are that 60% of women who suffer from migraines experience attacks that are associated with menstruation. Menstrual migraines are typically more debilitating, and less responsive to pharmacological treatment. This study evaluated the self-reported effectiveness and tolerability of Nerivio for the acute treatment of menstrual migraine, via a retrospective structured survey that was sent to 445 adult female device users, aged 18-55. One hundred and fifty-three women have filled the questionnaire. The analyzed dataset included questionnaires from all who reported experiencing menstrually-related migraines and have completed at least four Nerivio treatments, a total of 91 patients.


  • 75% of the participants reported that the treatment was at least moderately effective.
  • 100% of the participants reported that the treatment is at least moderately tolerable.
  • 45% reported satisfaction from the treatment.
  • Only 13.2% (12 participants) reported mild short-term side effects. No moderate or severe side effects were reported.

menstrual migraine percent responders graph

Conclusions: Nerivio may provide a safe, non-pharmacological alternative for the acute treatment of menstrual migraine.

Source: Nierenburg H et al. Remote Electrical Neuromodulation (REN) for the Acute Treatment of Menstrual Migraine: a Retrospective Survey Study of Effectiveness and Tolerability. Pain Ther. 2021 Jun 17. doi: 10.1007/s40122-021-00276-7. Epub ahead of print.